Spinal muscular atrophy is also an example of an autosomal recessive disorder that causes infantile death. It is a result of the loss of SMN1. Patients suffering from spinal atrophy have been found to lose SMN protein, which results in cell demise and deterioration of muscles. Other diseases that can be managed by the implementation of iPS include Huntingtonâ€™s disease, Parkinsonâ€™s disease, and Amyotrophic lateral sclerosis (Yildrim, 173).
Huntingtonâ€™s disease is caused by the repetition of expanded CAG in exon 1 of HTT. The severity of this disease is expressed by the aggregation of proteins within the nucleus of certain neurons. Parkinsonâ€™s disease is depicted by the production of neurons that produce dopamine throughout the brain. On the other hand, Amyotrophic lateral sclerosis is an adult sporadic genetic disease that leads to paralysis and atrophy of muscles. Although iPS contributes immensely to the production of neurological models, it cannot manage to produce all cells of neurological lineages. Due to this, neurological diseases cannot be managed completely.
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